A disease is any condition which results in the disorder of a structure or function in a living organism that is not due to any external injury. The study of disease is called pathology, which includes the study of cause. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens or by internal dysfunctions, particularly of the immune system, such as an immunodeficiency, or by a hypersensitivity, including allergies and autoimmunity.
The horseman on the white horse was clad in a showy and barbarous attire. [...] While his horse continued galloping, he was bending his bow in order to spread pestilence abroad. At his back swung the brass quiver filled with poisoned arrows, containing the germs of all diseases.
Vicente Blasco Ibáñez, The Four Horsemen of the Apocalypse (1916), (ch V).
To EU-funded Earth scientists, it is evident that many parts of the Earth's crust have been extracted from the underlying mantle. However, the timing of new crust formation and recycling of old crust has proven to be an elusive issue.
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